Adaptive mutation is defined as a process that, during nonlethal selections, produces mutations that relieve the selective pressure whether or not other, nonselected mutations are also produced. Examples of adaptive mutation or related phenomena have been reported in bacteria and yeast but not yet outside of microorganisms. A decade of research on adaptive mutation has revealed mechanisms that may increase mutation rates under adverse conditions. This article focuses on mechanisms that produce adaptive mutations in one strain of Escherichia coli, FC40. (...) These mechanisms include recombination-induced DNA replication, the placement of genes on a conjugal plasmid, and a transient mutator state. The implications of these various phenomena for adaptive evolution in microorganisms are discussed. BioEssays 22:1067–1074, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

En este artículo se estudian las razones que permiten establecer dos momentos en la filosofía kantiana de la historia, momentos que configuran una sutil evolución que, sin embargo, no contradice la intención esencial de la misma: El primero de ellos, anterior a 1790, se basa en un necesitarismo naturalista conjugado con la idea de la libertad como subsunción a la ley moral, lo cual dificulta la relación teoríapraxis, generando pesimismo histórico y, a la vez, no muy fundadas esperanzas en la (...) intervención del buen príncipe para producir el cambio político y social. El segundo momento, encara la historia desde el juicio teleológico, la admisión de los sentimientos como parte cooperante en la moral y la admiración a la revolución francesa, generando optimismo histórico, otorgando al derecho un papel decisivo en la construcción de la república noumenon y abriéndose a una concepción de la libertad más cercana al libre albedrío. (shrink)

In this essay, I set the book of Job in dialogue with a number of films from the robot science fiction subgenre. It is my intention to show that both sets of literature are deeply engaged with questions related to how creators and created things can interact, and that they deal with these questions in ways that illuminate and complement each other. The study proceeds in three phases. First, I develop a typology of robot science fiction as I see it (...) in Hollywood cinematic presentation. Second, I turn to unpack God's response to Job's complaint in Job 38. In this section, I focus particularly on God's self-description through constructive and parental metaphors. Finally, I suggest how reading these texts together can sharpen our understanding of the way in which the biblical narrative addresses relational dynamics between a creating God and humans as created beings. (shrink)

De Vries' mutation theory has not stood the test of time. The supposed mutations of Oenothera were in reality complex recombination phenomena, ultimately explicable in Mendelian terms, while instances of large-scale mutations were found wanting in other species. By 1915 the mutation theory had begun to lose its grip on the biological community; by de Vries' death in 1935 it was almost completely abandoned. Yet, as we have seen, during the first decade of the present century it achieved an enormous (...) popularity. As this paper has tried to suggest, one of the principal reasons for this was that de Vries' theory served as a banner around which a whole crowd of disaffected Darwinians or anti-Darwinians could rally. However, not all of those who favored de Vries did so for quite the same reasons. Underlying the multitude of views ran several common threads: a dissatisfaction with current Darwinian theory born out of misunderstanding natural selection, a general misunderstanding of the nature of species, and a prejudice against speculative, nontestable theories in biology.Supporters of de Vries were not the only opponents of Darwinism, nor was the mutation theory the only alternative to natural selection. In the early twentieth century a number of theories had been proposed to explain away the problems which Darwin had left unsolved. There was the idea of orthogenesis, championed by the American paleontologists Cope, Osborn and others; organic selection (or orthoplasy) was championed by M. M. Baldwin and C. Lloyd Morgan; there were the concepts of convergent evolution proposed by Hermann Friedmann, the theory of physiological selection by John George Romanes, and the concepts of reproductive divergence by H. M. Vernon. Virtually none of these men either accepted or were strong supporters of the de Vriesian theory, for each had his own particular ‘ism” to advocate as the major factor in evolution. The existence of a large number of such theories, each purporting to be the explanation, was characteristic of evolutionary theory at the turn of the century. It is to a large extent the emphasis on such fragmentary concepts that retarded development of the comprehensive theory of evolution which emerged in the 1920's and 1930's. For the historian, however, a study of these alternative theories is instructive in trying to understand the inherent difficulties which Dawwinian theory posed to biologists at the time. De Vries' mutation theory serves historically as a mirror to reflect the critical mood of a generation hostile to the theory of natural selection.It has often been claimed that it was impossible to understand the mechanism of natural selection until it could be placed in genetic and mathematical terms. It is certainly true that great strides have been made in population genetics and the treatment of evolutionary concepts with mathematical tools in the last forty years. But the very people who developed the genetical and mathematical approach to evolution were already convinced of the essential correctness of Darwinian theory before they started. Advances in an understanding of Mendelian heredity aided greatly in solving one important issue for evolutionists: the origin of variations. And the rigor with which selection acted could best be studied by observing changes in gene frequencies (calculated mathematically) over a number of generations. But as this paper has shown, two of the basic problems which biologists faced in evaluating Darwinian theory at the turn of the century-the nature of species, and the criteria of what constituted an acceptable explanation in biological science-could not be answered directly by mathematics. What mathematical and genetical theory did do was to help convince the skeptics of the validity of the Darwinian proposition.The change in explanatory criteria which many hailed as de Vries' most important contribution to evolutionary theory seems to have been part of a general emergence of twentieth-century biology from the domination of theorizers in the nineteenth. It also marked the emergence of America from the domination of biological, and particularly evolutionary, influence of Europeans. The change occurred in three areas: in the kinds of questions asked: testable versus non-testable; in the kind of data sought: quantitative versus qualitative; and in the kinds of theories proposed: analytical and reductive—the attempt to see complex processes in terms of simpler components-as opposed to synthetic and speculative. Although ultimately wrong in his idea, de Vries and his theories rode high on the wave of “experimentalism” which was the harbinger of a new era in evolutionary theory. (shrink)

En este artículo se estudian las razones que permiten establecer dos momentos en la filosofía kantiana de la historia, momentos que configuran una sutil evolución que, sin embargo, no contradice la intención esencial de la misma: El primero de ellos, anterior a 1790, se basa en un necesitarismo naturalista conjugado con la idea de la libertad como subsunción a la ley moral, lo cual dificulta la relación teoríapraxis, generando pesimismo histórico y, a la vez, no muy fundadas esperanzas en la (...) intervención del buen príncipe para producir el cambio político y social. El segundo momento, encara la historia desde el juicio teleológico, la admisión de los sentimientos como parte cooperante en la moral y la admiración a la revolución francesa, generando optimismo histórico, otorgando al derecho un papel decisivo en la construcción de la república noumenon y abriéndose a una concepción de la libertad más cercana al libre albedrío. (shrink)

En este artículo se estudian las razones que permiten establecer dos momentos en la filosofía kantiana de la historia, momentos que configuran una sutil evolución que, sin embargo, no contradice la intención esencial de la misma: El primero de ellos, anterior a 1790, se basa en un necesitarismo naturalista conjugado con la idea de la libertad como subsunción a la ley moral, lo cual dificulta la relación teoríapraxis, generando pesimismo histórico y, a la vez, no muy fundadas esperanzas en la (...) intervención del buen príncipe para producir el cambio político y social. El segundo momento, encara la historia desde el juicio teleológico, la admisión de los sentimientos como parte cooperante en la moral y la admiración a la revolución francesa, generando optimismo histórico, otorgando al derecho un papel decisivo en la construcción de la república noumenon y abriéndose a una concepción de la libertad más cercana al libre albedrío. (shrink)

This article analyses the accusation of nihilism that F. H. Jacobi made against Fichte in a letter of mars. 1799, imputation that lays on the personal conception ofJacobi about the reason as a negative capacity which only can destroy its objects. The letter in question implicates two different types of nihilism: a)The cosmological one, accepted by Fichte and named acosmism by him. It is only a reformulation of the sensible world from practical principIes, but doesn't suppose an annihilation or scorn (...) of this world. Qn the contrary, the religious view, for example, shows the world as a manifestation of godlite and, hased on moral exigencies, doesn~t admit the existence of death. Of course, the immortality isn't for a particular soul but for the order of moral actions (= God). b) The radical one, which doesn't exist in Fichte and lays on a bad interpretation of bis intellectual intuition assumed from a point of view next to Schelling. (shrink)

Plato's 'Euthyphro' is important because it gives an excellent example of Socratic dialogue in operation and of the connection of that dialectic with Plato's earlier 'Theory of Forms'. This edition of the dialogue provides a translation with interspersed commentary.

En este artículo se estudian las razones que permiten establecer dos momentos en la filosofía kantiana de la historia, momentos que configuran una sutil evolución que, sin embargo, no contradice la intención esencial de la misma: El primero de ellos, anterior a 1790, se basa en un necesitarismo naturalista conjugado con la idea de la libertad como subsunción a la ley moral, lo cual dificulta la relación teoríapraxis, generando pesimismo histórico y, a la vez, no muy fundadas esperanzas en la (...) intervención del buen príncipe para producir el cambio político y social. El segundo momento, encara la historia desde el juicio teleológico, la admisión de los sentimientos como parte cooperante en la moral y la admiración a la revolución francesa, generando optimismo histórico, otorgando al derecho un papel decisivo en la construcción de la república noumenon y abriéndose a una concepción de la libertad más cercana al libre albedrío. (shrink)

Ecclesia and Ethics considers the subject of Ecclesial Ethics within its theological, theoretical and exegetical contexts. Part one presents the biblical-theological foundations of an ecclesial ethic – examining issues such as creation, and Paul's theology of the Cross. Part two moves on to examine issues of character formation and community. Finally, part three presents a range of exegetical applications, which examine scripture and ethics in praxis. These essays look at hot-button issues such as the 'virtual self' in the digital age, (...) economics, and attitudes to war. The collection includes luminaries such as N.T. Wright, Michael J. Gorman, Stanley Hauerwas and Dennis Hollinger, as well as giving space to new theological and exegetical voices. As such Ecclesia and Ethics provides a challenging and contemporary examination of modern ethical debates in the light of up-to-date theology and exegesis. (shrink)

Background: Bioethics consultations are conducted in varied settings, including hospitals, universities, and other research institutions, but there is sparse information about bioethics consultations conducted in corporate settings such as pharmaceutical companies. The purpose of this article is to describe a bioethics consultation service at a pharmaceutical company, to report characteristics of consultations completed by the service over a 6-year period, and to share results of a consultation feedback survey. Methods: Data on the descriptive characteristics of bioethics consultations were collected from (...) 2008 to 2013 and analyzed in Excel 2007. Categorical data were analyzed via the pivot table function, and time-based variables were analyzed via formulas. The feedback survey was administered to consultation requesters from 2009 to 2012 and also analyzed in Excel 2007. Results: Over the 6-year period, 189 bioethics consultations were conducted. The number of consultations increased from five per year in 2008 to approximately one per week in 2013. During this time, the format of the consultation service was changed from a committee-only approach to a tiered approach (tailored to the needs of the case). The five most frequent topics were informed consent, early termination of a clinical trial, benefits and risks, human biological samples, and patient rights. The feedback survey results suggest the consultation service is well regarded overall and viewed as approachable, helpful, and responsive. Conclusions: Pharmaceutical bioethics consultation is a unique category of bioethics consultation that primarily focuses on pharmaceutical research and development but also touches on aspects of clinical ethics, business ethics, and organizational ethics. Results indicate there is a demand for a tiered bioethics consultation service within this pharmaceutical company and that advice was valued. This company's experience indicates that a bioethics consultation service raises awareness about bioethics, empowers employees to raise bioethical concerns, and helps them reason through challenging issues. (shrink)

Widely praised for its accessibility and its concentration on the metaphysical issues that are most central to the history of Greek philosophy, this book offers a valuable introduction to the works of the Presocratics, Plato, and Aristotle.

In their article describing the demographics and views of bioethicists in the U.S. today, Pierson et al. cite the calls to recognize the “moral and professional responsibility of those working in b...

Organizations have long struggled to find ways to reduce the occurrence of unethical behaviors by employees. Unfortunately, time theft, a common and costly form of ethical misconduct at work, has been understudied by ethics researchers. In order to remedy this gap in the literature, we used the theory of planned behavior (TPB) to investigate the antecedents of time theft, which includes behaviors such as arriving later to or leaving earlier from work than scheduled, taking additional or longer breaks than is (...) acceptable, and on-the-job daydreaming. We surveyed 135 employed undergraduate business students regarding the TPB variables at Time 1. Two months later, participants reported the frequency they engaged in time theft since Time 1. Results indicate that behavioral, normative, and control beliefs significantly predicted attitudes, subjective norms, and perceived behavioral control, respectively. Attitudes, subjective norms, and perceived behavioral control, in turn, were significantly related to time theft intentions, which predicted later enactment of time theft. Thus, employers can decrease time theft by primarily focusing on altering employees’ attitudes toward time theft, followed by reducing social pressures to engage in it, and lastly, by implementing organizational practices that make it difficult to commit time theft. (shrink)

Many philosophical debates take for granted that there is such a thing as ‘the’ common-sense conception of the phenomenon of interest. Debates about the nature of perception tend to take for granted that there is a single, coherent common-sense conception of vision, consistent with Direct Realism. This conception is often accorded an epistemic default status. We draw on philosophical and psychological literature on naïve theories and belief fragmentation to motivate the hypothesis that untutored common sense encompasses conflicting Direct Realist and (...) Indirect Realist conceptions: there is no such thing as ‘the’ common-sense conception of vision that could enjoy epistemic default status. To examine this hypothesis, a survey administered an agreement rating task with verbal and pictorial stimuli to lay participants. We found many laypeople simultaneously hold conflicting Direct Realist and Indirect Realist beliefs about vision. Against common assumptions, Direct Realist beliefs are not clearly dominant, and consistent adherence to Direct Realism is not the norm, but the exception. These findings are consistent with recent accounts of belief fragmentation. They forcefully challenge common methodology in philosophical debates about the nature of perception and beyond. (shrink)

A short time ago the idea of sustainable agriculture was accepted only at the extreme margins of the U. S. agricultural systems. Although sustainability has now become a major theme of many U. S. agricultural groups, there remains much under-explored terrain in the meaning of sustainable agriculture. A thorough examination of who and what we want to sustain and how we can sustain them is critical if sustainable agriculture is to be a practical improvement over conventional agriculture. In order to (...) begin this effort, this article analyzes contemporary sustainable agriculture discourse and suggests alternatives for reconceptualizing sustainable agriculture. In particular we look at three arenas of sustainable discourse-family farm/rural community preservation, food safety, and agricultural science-and address issues of class, race/ethnicity, and gender found in current sustainability positions. We find that while advocates of sustainability have succeeded in pushing agricultural researchers and policy makers to address environmental issues, we need to go much farther both in theory and practice in order to deal with equally important issues of social equity. © 1992 Kluwer Academic Publishers. (shrink)

Curiosity is widely acknowledged as a crucial aspect of children’s development and as an important part of the learning process, with prior research showing associations between curiosity and achievement. Despite this evidence, there is little research on the development of curiosity or on promoting curiosity in school settings, and measures of curiosity promotion in the classroom are absent from the published literature. This article introduces the Curiosity in Classrooms Framework coding protocol, a tool for observing and coding instructional practices that (...) support the promotion of curiosity. We describe the development of the framework and observation instrument and the results of a feasibility study using the protocol, which gives a descriptive overview of curiosity-promoting instruction in 35 elementary-level math lessons. Our discussion includes lessons learned from this work and suggestions for future research using the developed observation tool. (shrink)

In response to recent calls to extend the underlying theories used in the literature :375–413, 2005; Craft in J Bus Ethics 117:221–259, 2013), we review the usefulness of social norm theory in empirical business ethics research. We begin by identifying the seeds of social norm theory in Adam Smith’s The Theory of Moral Sentiments, the Glasgow Edition, Oxford University Press, Oxford, 1759/1790) seminal work, The Theory of Moral Sentiments. Next, we introduce recent theory in social norm activation by Bicchieri and (...) compare the new theory to two theoretical frameworks found in the literature: Kohlberg’s Handbook of socialization theory and research, Rand McNally, Chicago, IL, 1969; in: Lickona Moral development and behavior, Holt, Rinehart & Winston, New York, 1976) theory of moral development and Cialdini and Trost’s The handbook of social psychology, Oxford University Press, Boston, 1998) taxonomy of social norms. We argue that the new theory provides useful insights by emphasizing the ability of situational cues and information to generate common expectations for social/moral norms. The theory is particularly useful for empirical research in business ethics because it gives both organizational and individual factors a role in motivating norm-based behavior. To demonstrate this usefulness, we present examples where the theory has been effectively applied in experimental accounting research to generate new insights. We conclude by citing specific examples where the theory may prove useful in empirical business ethics research. (shrink)

As one of the most important ethicists to emerge since the Second World War, Alan Gewirth continues to influence philosophical debates concerning morality. In this ground-breaking book, Gewirth's neo-Kantianism, and the communitarian problems discussed, form a dialogue on the foundation of moral theory. Themes of agent-centered constraints, the formal structure of theories, and the relationship between freedom and duty are examined along with such new perspectives as feminism, the Stoics, and Sartre. Gewirth offers a picture of the philosopher's theory and (...) its applications, providing a richer, more complete critical assessement than any which has occurred to date. (shrink)

Hastings Center Report, Volume 52, Issue S1, Page S3-S11, March‐April 2022.

The present study explored a multi‐construct model of moral development. Variables commonly seen in the moral development literature, such as family interactions, spiritual life, ascription to various sources of moral authority, empathy, shame, guilt and moral judgement competence, were investigated. Results from the current study support previous research that the three moral emotions of empathy, shame and guilt interrelate. Further, it was found that the relationship one has with a higher power (spirituality) involves empathy and guilt. Implications for moral education (...) are discussed. Future research should continue to explore a multi‐construct model of morality. (shrink)

R.E. Allen's superb new translations of four Socratic dialogues—_Ion_, _Hippias Minor_, _Laches_, and _Protagoras_—bring these classic texts to life for modern readers. Allen introduces and comments on the dialogues in an accessible way, inviting the reader to reexamine the issues continually raised in Plato's works. In his detailed commentary, Allen closely examines the major themes and central arguments of each dialogue, with particular emphasis on _Protagoras_. He clarifies each of Plato's arguments and its refutation; places the themes (...) in historical perspective; ties each theme to interpretations of rival translations; and links the philosopher's thought to trends in late modern philosophy. Topics discussed include: whether virtue is an art, whether wisdom and courage are logically equivalent, whether virtue is knowledge, and whether to know the good is to do it. Allen connects his discussion of these issues to the Benthamite tradition of hedonism and utilitarianism and to the ethical theories of Mill, Sidgwick, Moore, and Freud. (shrink)

In this book, R.E. Allen provides a translation of the 'Parmenides' along with a structural analysis that procedes on the assumption that formal elements, logical and dramatic, are important to its interpretation and that the argument of the Parmenides is aporetic, a statement of metaphysical perplexities.